Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, Alvarez R, Schiavone EM, Ferrara F, Bresciani F, Weisz A, de Lera AR, Gronemeyer H, Altucci L

Nat Med. 2024 11 20;:

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L

Cell Death Differ. 2023 04 26;:1-58

Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs.

Koshy A, Mathieux E, Stüder F, Bramoulle A, Lieb M, Colombo BM, Gronemeyer H, Mendoza-Parra MA

Life Sci Alliance. 2023 02;6(2):

Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity.

Huyghe A, Furlan G, Schroeder J, Cascales E, Trajkova A, Ruel M, Stüder F, Larcombe M, Yang Sun YB, Mugnier F, De Matteo L, Baygin A, Wang J, Yu Y, Rama N, Gibert B, Kielbassa J, Tonon L, Wajda P, Gadot N, Brevet M, Siouda M, Mulligan P, Dante R, Liu P, Gronemeyer H, Mendoza-Parra M, Polo JM, Lavial F

Nat Cell Biol. 2022 09 8;:

Complexity against current cancer research - are we on the wrong track?

Kasikci Y, Gronemeyer H

Int J Cancer. 2021 Dec 18;:

Reductionism that leads to manuscript rejection.

Gronemeyer H

Int J Cancer. 2021 Dec 14;:

Big Data: The good, the bad and the ugly.

Gronemeyer H, Souren NY

Int J Cancer. 2021 Feb 2;:

Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention.

Kumar A, Kasikci Y, Badredine A, Azzag K, Quintyn Ranty ML, Zaidi F, Aragou N, Mazerolles C, Malavaud B, Mendoza-Parra MA, Vandel L, Gronemeyer H

Am J Cancer Res. 2021 ;11(11):5299-5318

Promising strategies: Combination of epigenetic inhibitors for cancer therapy.

Gronemeyer H

Int. J. Cancer. 2020 Jun 29;:e33142

CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity.

Siouda M, Dujardin AD, Barbollat-Boutrand L, Mendoza-Parra MA, Gibert B, Ouzounova M, Bouaoud J, Tonon L, Robert M, Foy JP, Lavergne V, Manie SN, Viari A, Puisieux A, Ichim G, Gronemeyer H, Saintigny P, Mulligan P

iScience. 2020 May 6;23(6):101141

A comprehensive resource for retrieving, visualizing, and integrating functional genomics data.

Blum M, Cholley PE, Malysheva V, Nicaise S, Moehlin J, Gronemeyer H, Mendoza-Parra MA

Life Sci Alliance. 2020 Jan;3(1):

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

Fauquier L, Azzag K, Parra MAM, Quillien A, Boulet M, Diouf S, Carnac G, Waltzer L, Gronemeyer H, Vandel L

Sci Rep. 2018 Aug 22;8(1):12629

Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function.

Fujii S, Mori S, Kagechika H, Mendoza Parra MA, Gronemeyer H

Bioorg. Med. Chem. Lett.. 2018 Jun 6;:

Senescence-associated reprogramming promotes cancer stemness.

Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA

Nature. 2018 01 4;553(7686):96-100

Modeling gene-regulatory networks to describe cell fate transitions and predict master regulators.

Cholley PE, Moehlin J, Rohmer A, Zilliox V, Nicaise S, Gronemeyer H, Mendoza-Parra MA

NPJ Syst Biol Appl. 2018 ;4:29

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells.

Shlyakhtina Y, Pavet V, Gronemeyer H

Cell Death Dis. 2017 Aug 31;8(8):e3025

Epimetheus - a multi-profile normalizer for epigenomic sequencing data.

Saleem MM, Mendoza-Parra MA, Cholley PE, Blum M, Gronemeyer H

BMC Bioinformatics. 2017 May;18(1):259

Reconstructed cell fate-regulatory programs in stem cells reveal hierarchies and key factors of neurogenesis.

Mendoza-Parra MA, Malysheva V, Mohamed Saleem MA, Lieb M, Godel A, Gronemeyer H

Genome Res.. 2016 Nov;26(11):1505-1519

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation.

Brier AB, Loft A, Madsen JG, Rosengren T, Nielsen R, Schmidt SF, Liu Z, Yan Q, Gronemeyer H, Mandrup S

Nucleic Acids Res.. 2016 Nov;:

LOGIQA: a database dedicated to long-range genome interactions quality assessment.

Mendoza-Parra MA, Blum M, Malysheva V, Cholley PE, Gronemeyer H

BMC Genomics. 2016 May;17:355

Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis.

Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H

Genome Med. 2016 05;8(1):57

Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification.

Mendoza-Parra MA, Saravaki V, Cholley PE, Blum M, Billoré B, Gronemeyer H

F1000Res. 2016 ;5:54

NGS-QC Generator: A Quality Control System for ChIP-Seq and Related Deep Sequencing-Generated Datasets.

Mendoza-Parra MA, Saleem MA, Blum M, Cholley PE, Gronemeyer H

Methods Mol. Biol.. 2016 ;1418:243-65

TARDIS, a targeted RNA directional sequencing method for rare RNA discovery.

Portal MM, Pavet V, Erb C, Gronemeyer H

Nat Protoc. 2015 Dec;10(12):1915-38

Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.

Qiu JJ, Zeisig BB, Li S, Liu W, Chu H, Song Y, Giordano A, Schwaller J, Gronemeyer H, Dong S, So CW

Leukemia. 2015 May;29(5):1153-62

Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids.

Alvarez S, Lieb M, Martinez C, Khanwalkar H, Rodriguez-Barrios F, Alvarez R, Gronemeyer H, de Lera AR

ChemMedChem. 2015 May 26

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.

Chaligné R, Popova T, Mendoza-Parra MA, Saleem MA, Gentien D, Ban K, Piolot T, Leroy O, Mariani O, Gronemeyer H, Vincent-Salomon A, Stern MH, Heard E

Genome Res.. 2015 Apr;25(4):488-503

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RARbeta, NR1B2) Selective Agonist.

Nadendla E, Teyssier C, Delfosse V, Vivat V, Krishnasamy G, Gronemeyer H, Bourguet W, Germain P

PLoS One. 2015 May 1;10(5):e0123195

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Munoz-Pinedo C, Nunez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G

Cell Death Differ. 2015 Jan;22(1):58-73

Human cells contain natural double-stranded RNAs with potential regulatory functions.

Portal MM, Pavet V, Erb C, Gronemeyer H

Nat Struct Mol Biol. 2015 Jan;22(1):89-97

Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.

Pulka-Ziach K, Pavet V, Chekkat N, Estieu-Gionnet K, Rohac R, Lechner MC, Smulski CR, Zeder-Lutz G, Altschuh D, Gronemeyer H, Fournel S, Odaert B, Guichard G

Chembiochem. 2015 Jan;16(2):293-301

Assessing quality standards for ChIP-seq and related massive parallel sequencing-generated datasets: When rating goes beyond avoiding the crisis.

Mendoza-Parra MA, Gronemeyer H

Genom Data. 2014 Aug 14;2:268-73

Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis.

Vjetrovic J, Shankaranarayanan P, Mendoza-Parra MA, Gronemeyer H

Aging Cell. 2014 Jun;13(3):487-96

Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold.

Martinez C, Lieb M, Alvarez S, Rodriguez-Barrios F, Alvarez R, Khanwalkar H, Gronemeyer H, de Lera AR

ACS Med Chem Lett. 2014 Mar 19;5(5):533-7

Functions, therapeutic applications, and synthesis of retinoids and carotenoids.

Alvarez R, Vaz B, Gronemeyer H, de Lera AR

Chem Rev. 2014 Jan 8;114(1):1-125

Integrative genomics to dissect retinoid functions.

Mendoza-Parra MA, Gronemeyer H

Subcell Biochem. 2014;70:181-202

Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.

Pavet V, Shlyakhtina Y, He T, Ceschin DG, Kohonen P, Perala M, Kallioniemi O, Gronemeyer H

Cell Death Dis. 2014 Jan 30;5:e1043

Genome-wide studies of nuclear receptors in cell fate decisions.

Mendoza-Parra MA, Gronemeyer H

Semin Cell Dev Biol. 2013 Dec;24(10-12):706-15

A quality control system for profiles obtained by ChIP sequencing.

Mendoza-Parra MA, Van Gool W, Mohamed Saleem MA, Ceschin DG, Gronemeyer H

Nucleic Acids Res. 2013 Nov;41(21):e196

Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.

Ivanova D, Gronemeyer H, Steinberg P, Nau H

Arch Toxicol. 2013 Feb;87(2):303-10

Characterising ChIP-seq binding patterns by model-based peak shape deconvolution.

Mendoza-Parra MA, Nowicka M, Van Gool W, Gronemeyer H

BMC Genomics. 2013 Nov 26;14:834

A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.

Garcia-Dominguez P, Weiss M, Lepore I, Alvarez R, Altucci L, Gronemeyer H, de Lera AR

ChemMedChem. 2012 Dec;7(12):2101-12

Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities.

Pereira R, Benedetti R, Perez-Rodriguez S, Nebbioso A, Garcia-Rodriguez J, Carafa V, Stuhldreier M, Conte M, Rodriguez-Barrios F, Stunnenberg HG, Gronemeyer H, Altucci L, de Lera AR

J Med Chem. 2012 Nov 26;55(22):9467-91

Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.

Gluyas JB, Burschka C, Dorrich S, Vallet J, Gronemeyer H, Tacke R

Org Biomol Chem. 2012 Sep 14;10(34):6914-29

POLYPHEMUS: R package for comparative analysis of RNA polymerase II ChIP-seq profiles by non-linear normalization.

Mendoza-Parra MA, Sankar M, Walia M, Gronemeyer H

Nucleic Acids Res. 2012 Feb;40(4):e30

Single-tube linear DNA amplification for genome-wide studies using a few thousand cells.

Shankaranarayanan P, Mendoza-Parra MA, van Gool W, Trindade LM, Gronemeyer H

Nat Protoc. 2012 Jan 26;7(2):328-38

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB

PLoS One. 2012;7(3):e32526

Retinoid receptors and therapeutic applications of RAR/RXR modulators.

Maire Al, Alvarez S, Shankaranarayanan P, Lera AR, Bourguet W, Gronemeyer H

Curr Top Med Chem. 2012;12(6):505-27.

Death receptor pathway activation and increase of ROS production by the triple epigenetic inhibitor UVI5008.

Nebbioso A, Pereira R, Khanwalkar H, Matarese F, Garcia-Rodriguez J, Miceli M, Logie C, Kedinger V, Ferrara F, Stunnenberg HG, de Lera AR, Gronemeyer H, Altucci L

Mol Cancer Ther. 2011 Dec;10(12):2394-404

Epigenetic multiple modulators.

Alvarez R, Altucci L, Gronemeyer H, de Lera AR

Curr Top Med Chem. 2011 Nov;11(22):2749-87.

Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B.

Garcia-Dominguez P, Lepore I, Erb C, Gronemeyer H, Altucci L, Alvarez R, de Lera AR

Org Biomol Chem. 2011 Oct 21;9(20):6979-87

Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.

Ivanova D, Gronemeyer H, de Lera AR

ChemMedChem. 2011 Aug 1;6(8):1518-29

Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.

Garcia J, Franci G, Pereira R, Benedetti R, Nebbioso A, Rodriguez-Barrios F, Gronemeyer H, Altucci L, de Lera AR

Bioorg Med Chem. 2011 Jun 15;19(12):3637-49

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

Ceschin DG, Walia M, Wenk SS, Duboe C, Gaudon C, Xiao Y, Fauquier L, Sankar M, Vandel L, Gronemeyer H

Genes Dev. 2011 Jun 1;25(11):1132-46

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

Sun X, Wu Y, Chen B, Zhang Z, Zhou W, Tong Y, Yuan J, Xia K, Gronemeyer H, Flavell RA, Song W

J Biol Chem. 2011 Mar 18;286(11):9049-62

Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics.

Mendoza-Parra MA, Walia M, Sankar M, Gronemeyer H

Mol Syst Biol. 2011 Oct 11;7:538

Retinoic acid receptor modulators: a perspective on recent advances and promises.

Alvarez S, Bourguet W, Gronemeyer H, de Lera AR

Expert Opin Ther Pat. 2011 Jan;21(1):55-63

Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis.

Kedinger V, Muller S, Gronemeyer H

Mol Cancer. 2011 Apr 4;10:34.

Towards novel paradigms for cancer therapy.

Pavet V, Portal MM, Moulin JC, Herbrecht R, Gronemeyer H

Oncogene. 2011 Jan 6;30(1):1-20

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.

Nebbioso A, Dell'Aversana C, Bugge A, Sarno R, Valente S, Rotili D, Manzo F, Teti D, Mandrup S, Ciana P, Maggi A, Mai A, Gronemeyer H, Altucci L

J Mol Endocrinol. 2010 Oct;45(4):219-28

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.

le Maire A, Teyssier C, Erb C, Grimaldi M, Alvarez S, de Lera AR, Balaguer P, Gronemeyer H, Royer CA, Germain P, Bourguet W

Nat Struct Mol Biol. 2010 Jul;17(7):801-7

Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge.

Mikesch JH, Gronemeyer H, So CW

Cancer Cell. 2010 Feb 17;17(2):112-4.

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.

Pavet V, Beyrath J, Pardin C, Morizot A, Lechner MC, Briand JP, Wendland M, Maison W, Fournel S, Micheau O, Guichard G, Gronemeyer H

Cancer Res. 2010 Feb 1;70(3):1101-10

Inverse agonists and antagonists of retinoid receptors.

Bourguet W, de Lera AR, Gronemeyer H

Methods Enzymol. 2010;485:161-95.

Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S

Blood. 2010 Jan 21;115(3):643-52

Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.

Jimenez-Lara AM, Aranda A, Gronemeyer H

Mol Cancer. 2010 Jan 26;9:15.

Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.

Tacke R, Muller V, Buttner MW, Lippert WP, Bertermann R, Daiss JO, Khanwalkar H, Furst A, Gaudon C, Gronemeyer H

ChemMedChem. 2009 Nov;4(11):1797-802.

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function.

Alvarez S, Khanwalkar H, Alvarez R, Erb C, Martinez C, Rodriguez-Barrios F, Germain P, Gronemeyer H, de Lera AR

ChemMedChem. 2009 Oct;4(10):1630-40.

Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.

Shankaranarayanan P, Rossin A, Khanwalkar H, Alvarez S, Alvarez R, Jacobson A, Nebbioso A, de Lera AR, Altucci L, Gronemeyer H

Cancer Cell. 2009 Sep 8;16(3):220-31

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Jaattela M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nunez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G

Cell Death Differ. 2009 Aug;16(8):1093-107

Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.

Alvarez S, Alvarez R, Khanwalkar H, Germain P, Lemaire G, Rodriguez-Barrios F, Gronemeyer H, de Lera AR

Bioorg Med Chem. 2009 Jul 1;17(13):4345-59

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

Nebbioso A, Manzo F, Miceli M, Conte M, Manente L, Baldi A, De Luca A, Rotili D, Valente S, Mai A, Usiello A, Gronemeyer H, Altucci L

EMBO Rep. 2009 Jul;10(7):776-82

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.

Lippert WP, Burschka C, Gotz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R

ChemMedChem. 2009 Jul;4(7):1143-52.

Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.

Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H

Chem Biol. 2009 May 29;16(5):479-89.

Highly potent naphthofuran-based retinoic acid receptor agonists.

Santin EP, Khanwalkar H, Voegel J, Collette P, Mauvais P, Gronemeyer H, de Lera AR

ChemMedChem. 2009 May;4(5):780-91.

Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtha len-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.

Perez Santin E, Germain P, Quillard F, Khanwalkar H, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W

J Med Chem. 2009 May 28;52(10):3150-8.

Fingering modulators of retinoic acid signaling identifies new prognostic marker for neuroblastoma.

Gronemeyer H, Zelent A

Cancer Cell. 2009 Apr 7;15(4):249-51.

Allosteric effects govern nuclear receptor action: DNA appears as a player.

Gronemeyer H, Bourguet W

Sci Signal. 2009 Jun 2;2(73):pe34.

New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.

Alvarez S, Pazos-Randulfe Y, Khanwalkar H, Germain P, Alvarez R, Gronemeyer H, de Lera AR

Bioorg Med Chem. 2008 Nov 15;16(22):9719-28

A new era of cancer therapy: cancer cell targeted therapies are coming of age.

Voltz E, Gronemeyer H

Int J Biochem Cell Biol. 2008;40(1):1-8

Retinoic acid analogues inhibit human herpesvirus 8 replication

Caselli E, Galvan M, Santoni F, Alvarez S, de Lera AR, Ivanova D, Gronemeyer H, Caruso A, Guidoboni M, Cassai E, Dolcetti R, Di Luca D

Antivir Ther. 2008;13(2):199-209.

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.

Epping MT, Wang L, Plumb JA, Lieb M, Gronemeyer H, Brown R, Bernards R

Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17777-82

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.

Nahoum V, Perez E, Germain P, Rodriguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17323-8

RAR and RXR modulation in cancer and metabolic disease.

Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H

Nat Rev Drug Discov. 2007 Oct;6(10):793-810.

Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology.

Buttner MW, Burschka C, Daiss JO, Ivanova D, Rochel N, Kammerer S, Peluso-Iltis C, Bindler A, Gaudon C, Germain P, Moras D, Gronemeyer H, Tacke R

Chembiochem. 2007 Sep 24;8(14):1688-99.

Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.

Zeisig BB, Kwok C, Zelent A, Shankaranarayanan P, Gronemeyer H, Dong S, So CW

Cancer Cell. 2007 Jul;12(1):36-51.

HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.

Tsapis M, Lieb M, Manzo F, Shankaranarayanan P, Herbrecht R, Lutz P, Gronemeyer H

Int J Biochem Cell Biol. 2007;39(7-8):1500-9

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.

Alvarez S, Germain P, Alvarez R, Rodriguez-Barrios F, Gronemeyer H, de Lera AR

Int J Biochem Cell Biol. 2007;39(7-8):1406-15

Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARbeta/delta agonists.

Pereira R, Furst A, Iglesias B, Germain P, Gronemeyer H, de Lera AR

Org Biomol Chem. 2006 Dec 21;4(24):4514-25

International Union of Pharmacology. LX. Retinoic acid receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H

Pharmacol Rev. 2006 Dec;58(4):712-25.

International Union of Pharmacology. LXIII. Retinoid X receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H

Pharmacol Rev. 2006 Dec;58(4):760-72.

Neofunctionalization in vertebrates: the example of retinoic acid receptors.

Escriva H, Bertrand S, Germain P, Robinson-Rechavi M, Umbhauer M, Cartry J, Duffraisse M, Holland L, Gronemeyer H, Laudet V

PLoS Genet. 2006 Jul;2(7):e102.

Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.

Yin W, Rossin A, Clifford JL, Gronemeyer H

Oncogene. 2006 Jun 22;25(26):3735-44

Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.

Nagy L, Schule R, Gronemeyer H

EMBO Rep. 2006 Jun;7(6):579-84

Cross-talk of vitamin D and glucocorticoids in hippocampal cells.

Obradovic D, Gronemeyer H, Lutz B, Rein T

J Neurochem. 2006 Jan;96(2):500-9

Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.

Pereira R, Gaudon C, Iglesias B, Germain P, Gronemeyer H, de Lera AR

Bioorg Med Chem Lett. 2006 Jan 1;16(1):49-54

Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.

Lou YR, Miettinen S, Kagechika H, Gronemeyer H, Tuohimaa P

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1973-81

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.

Altucci L, Rossin A, Hirsch O, Nebbioso A, Vitoux D, Wilhelm E, Guidez F, De Simone M, Schiavone EM, Grimwade D, Zelent A, de Thé H, Gronemeyer H

Cancer Res.. 2005 Oct;65(19):8754-65

Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs.

Yin W, Raffelsberger W, Gronemeyer H

Int J Biochem Cell Biol. 2005 Aug;37(8):1696-708

TRAIL: at the center of drugable anti-tumor pathways.

Clarke N, Nebbioso A, Altucci L, Gronemeyer H

Cell Cycle. 2005 Jul;4(7):914-8

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Perez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W

J Biol Chem. 2005 Jan 14;280(2):1625-33

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.

Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, Alvarez R, Schiavone EM, Ferrara F, Bresciani F, Weisz A, de Lera AR, Gronemeyer H, Altucci L

Nat Med. 2005 Jan;11(1):77-84