Does the association of (18)F-FDG uptake intensity and lesion topography reveal histological phenotype and tumor differentiation in esophageal cancer?
Fiche publication
Date publication
septembre 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles, Pr OLIVIER Pierre, Pr ROHR Serge, Pr IMPERIALE Alessio, Pr BRIGAND Cécile
Tous les auteurs :
Imperiale A, Cimarelli S, Brigand C, Faure G, Karcher G, Rohr S, Atlani D, Olivier P
Lien Pubmed
Résumé
In daily clinical practice, the esophageal squamous cell cancer (ESCC) is considered to be more (18)F-FDG avid than adenocarcinoma (EAD). To date, the few studies concerning the existence of a real metabolic difference based on esophageal cancer (EC) histology, show divergent and not definitive results. A retrospective analysis of (18)F-FDG PET/CT of 87 patients with ESCC and EAD was performed to investigate the role played by both histopathological subtype and tumor differentiation in the characterization of glucose metabolic profile of EC. Esophageal squamous cell cancer was well differentiated (WD) in 42 cases and poorly differentiated (PD) in 12 patients. Twenty-one of the 33 patients had WD EAD, while 12 had a PD EAD. The (18)F-FDG maximal standardized uptake value (SUV (max) ) was determined for all lesions and used for inter and intra-group comparison. In ESCC, the SUV (max) ranged from 4 to 31 with a mean value of 16+/-6. In EAD, the SUV(max) ranged from 2 to 25 with a mean value of 10+/-6. A statistically significant difference (P
Référence
Hell J Nucl Med. 2011 Sep;14(3):239-42.