Immune ambivalence: The schizophrenic bleomycin.
Fiche publication
Date publication
septembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
Tous les auteurs :
Mignot G, Bugaut H, Ghiringhelli F
Lien Pubmed
Résumé
In addition to cytotoxic effects, anticancer agents can exert multiple immunomodulatory functions. We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+ T cell responses; and 2) induce the secretion of transforming growth factor beta (TGFbeta), which stimulates regulatory T cells. This suggests that bleomycin may be favorably combined with TGFbeta-targeting strategies.
Référence
Oncoimmunology. 2013 Sep 1;2(9):e25737