The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age.
Fiche publication
Date publication
juin 2023
Journal
Frontiers in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Mme BOUARD Adeline, Dr MANSI Laura, Dr VIENOT Angélique, Dr KROEMER Marie
Tous les auteurs :
Orillard E, Spehner L, Mansi L, Bouard A, Falcoz A, Lepiller Q, Renaude E, Pallandre JR, Vienot A, Kroemer M, Borg C
Lien Pubmed
Résumé
Cancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure of COVID-19 vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter COVID-19 vaccine-induced immunity.
Mots clés
COVID-19, vaccination, T lymphocyte (T-cell), cancer patient, predictive biomarker, senescence
Référence
Front Immunol. 2023 06 2;14:1160664