Novel fat taste receptor agonists curtail progressive weight gain in obese male mice.
Fiche publication
Date publication
novembre 2022
Journal
Cellular and molecular gastroenterology and hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LIRUSSI Frédéric, Pr KAHN Naim, Dr HICHAMI Aziz, Pr SCHMITT Antonin
Tous les auteurs :
Khan AS, Hichami A, Murtaza B, Louillat-Habermeyer ML, Ramseyer C, Azadi M, Yesylevskyy S, Mangin F, Lirussi F, Leemput J, Merlin JF, Schmitt A, Suliman M, Bayardon J, Semnanian S, Jugé S, Khan NA
Lien Pubmed
Résumé
The spontaneous preference for dietary lipids is, principally, regulated by two lingual fat taste receptors, i.e., CD36 and GPR120. Obese animals and most of human subjects exhibit low oro-sensory perception of dietary fat because of malfunctioning of these taste receptors. Our aim was to target the two fat taste receptors by newly synthesized high affinity fatty acid agonists to decrease fat-rich food intake and obesity.
Mots clés
CD36, Fat taste, GPR120, lipids, obesity
Référence
Cell Mol Gastroenterol Hepatol. 2022 11 18;: