Targeting coagulation to unlock antitumor immunity?
Fiche publication
Date publication
janvier 2022
Journal
Oncoimmunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
Tous les auteurs :
Galmiche A, Saidak Z, Ghiringhelli F
Lien Pubmed
Résumé
Besides a number of physical consequences (reduced blood supply, stabilization of circulating tumor microemboli, shielding from the attack of immune cells), the coagulation cascade may specifically regulate antitumor immunity. We recently applied systems biology and genomics to explore the regulation of the tumor immune microenvironment by coagulation.
Mots clés
Coagulome, antigen presentation, antitumor immunity, genomics, tissue factor, tumor microenvironment
Référence
Oncoimmunology. 2022 ;11(1):2045696