Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer.
Fiche publication
Date publication
juin 2021
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Pr GHIRINGHELLI François, Dr LADOIRE Sylvain, Mme TRUNTZER Caroline, Dr LIMAGNE Emeric, Dr DERANGERE Valentin, Dr THIBAUDIN Marion
Tous les auteurs :
Klopfenstein Q, Derangère V, Arnould L, Thibaudin M, Limagne E, Ghiringhelli F, Truntzer C, Ladoire S
Lien Pubmed
Résumé
The prognosis of early breast cancer is linked to clinic-pathological stage and the molecular characteristics of intrinsic tumor cells. In some patients, the amount and quality of tumor-infiltrating immune cells appear to affect long term outcome. We aimed to propose a new tool to estimate immune infiltrate, and link these factors to patient prognosis according to breast cancer molecular subtypes.
Mots clés
biostatistics, breast neoplasms, tumor biomarkers, tumor microenvironment
Référence
J Immunother Cancer. 2021 06;9(6):