FLUORESCENCE IMAGING ANALYSIS OF DISTRIBUTION OF INDOCYANINE GREEN IN MOLECULAR AND NANOFORM IN TUMOR MODEL.
Fiche publication
Date publication
novembre 2021
Journal
Photodiagnosis and photodynamic therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina
Tous les auteurs :
Farrakhova D, Maklygina Y, Romanishkin I, Yakovlev D, Plyutinskaya A, Bezdetnaya L, Loschenov V
Lien Pubmed
Résumé
The efficient intraoperative identification of tumors requires the development of highly specific near-infrared (NIR) probes as contrast agents. One of the most effective dyes existing in clinic oncology is Indocyanine Green (ICG). However, ICG has a rapid excretion, thus ruling out its extended accumulation in pathological tissues therefore limiting its clinical applications. ICG colloid solution (ICG NPs) consists predominantly of J-aggregates and to a lesser extent of H-aggregates and monomers. In the present study we assessed the spectral properties of ICG nanoforms in preclinical models.
Mots clés
fluorescent dyes, fluorescent navigation, head and neck cancer, indocyanine green, nanoparticles, near-infrared range, video-fluorescent imaging
Référence
Photodiagnosis Photodyn Ther. 2021 Nov 19;:102636