and impact of high-dose rate radiotherapy using flattening-filter-free beams on the anti-tumor immune response.
Fiche publication
Date publication
septembre 2020
Journal
Clinical and translational radiation oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOIDOT Romain, Pr GHIRINGHELLI François, Dr MIRJOLET Céline, Dr LIMAGNE Emeric
Tous les auteurs :
Laurent PA, Kownacka A, Boidot R, Richard C, Limagne E, Morgand V, Froidurot L, Bonin C, Aubignac L, Ghiringhelli F, Créhange G, Mirjolet C
Lien Pubmed
Résumé
Modern accelerators have the "flattening filter-free" (FFF) technique to deliver RT with a moderate high-dose rate, currently used in limited clinical indications. No scientifically established data are currently available on the possible effects of this high dose rate on the anti-tumor immune response. We therefore propose here to study these effects in a preclinical CT26 murine colorectal tumor model.
Mots clés
Dose rate modulation, Flattening filter free, Radio-induced immune response
Référence
Clin Transl Radiat Oncol. 2020 Sep;24:116-122