Intraabdominal urokinase in the treatment of loculated infected ascites in cirrhosis.

Fiche publication


Date publication

juillet 2020

Journal

Clinics and research in hepatology and gastroenterology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr HABERSETZER François, Pr PESSAUX Patrick


Tous les auteurs :
Tripon S, Mayer P, Svab A, Habersetzer F, Pessaux P, Baumert TF, Enescu I

Résumé

Cirrhotic patients may present loculated ascites. We report a case of a 49-years old patient with cirrhosis and loculated infected ascites. Conventional and ultrasound (US)-guided paracentesis were ineffective. Moreover, US-guided drainages with 10 F drains could drain only small quantities of ascites localized in the largest loculated areas. Despite an adapted and long antibiotic therapy, the infection persisted. Intraabdominal fibrinolysis allowed the destruction of the fibrin septa, a better drainage and the sterilization of the ascites fluid. This is the first case report of effective intraabdominal fibrinolysis with urokinase in difficult to treat loculated infected ascites.

Mots clés

Cirrhosis, Fibrinolysis, Loculated ascites

Référence

Clin Res Hepatol Gastroenterol. 2020 Jul 9;: