Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.
Fiche publication
Date publication
mai 2020
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen, Pr GHIRINGHELLI François, Dr REBE Cédric, Dr CHALMIN Fanny, Dr LIMAGNE Emeric, Dr DERANGERE Valentin
Tous les auteurs :
Pilot T, Fratti A, Thinselin C, Perrichet A, Demontoux L, Limagne E, Derangère V, Ilie A, Ndiaye M, Jacquin E, Garrido C, Ghiringhelli F, Chalmin F, Rébé C
Lien Pubmed
Résumé
We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome. NLRP3 activation leads to caspase-1 activation and production of IL-1β, which in turn favors secondary tumor growth. We decided to explore the effects of either a heat shock (HS) or the deficiency in heat shock protein (HSP) 70, previously shown to respectively inhibit or increase NLRP3 inflammasome activation in macrophages.
Mots clés
cytokines, immunity, cellular, immunomodulation, inflammation, inflammation mediators
Référence
J Immunother Cancer. 2020 May;8(1):