Implantation of the Auditory Nerve via the Middle Ear Cavity in Rats with Partial Hearing Preservation.
Fiche publication
Date publication
janvier 2016
Journal
Audiology & neuro-otology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTIN Laurent
Tous les auteurs :
Guigou C, Leterme G, Pasquis B, Martin L, Tourrel G, Bretillon L, Bozorg Grayeli A
Lien Pubmed
Résumé
The aim of this study was to evaluate the residual hearing function and cochlear morphology after auditory nerve implantation via middle ear spaces in rats. A titanium rod (1.5 mm long and 0.3 mm thick) coated with Parylene was inserted in the cochlear apex in the direction of the modiolus in 9 Wistar rats. Auditory brainstem-evoked responses to tone bursts at 2, 8, 12 and 32 kHz were recorded before surgery and on postoperative days 0, 2, 15 and 30. Eight cochleas were examined microscopically. The rod was inside the modiolus in 4, and partly or totally outside the modiolus in 4 animals. Residual hearing was present in all cases. The average threshold shift in cochleas with modiolar implant was 39 ± 11.2, 54 ± 9.7, 48 ± 20.3 and 43 ± 21.3 dB SPL on postoperative days 0, 2, 15 and 30, respectively. The transmodiolar approach allows a minimally invasive cochlear implantation and a partial hearing preservation.
Mots clés
Animals, Audiometry, Pure-Tone, Auditory Threshold, physiology, Cochlear Nerve, transplantation, Ear, Middle, physiology, Evoked Potentials, Auditory, Brain Stem, physiology, Hearing, physiology, Male, Rats, Rats, Wistar
Référence
Audiol. Neurootol.. 2016 ;21(2):98-104