LIN7A is a major determinant of cell-polarity defects in breast carcinomas.

Fiche publication


Date publication

février 2016

Journal

Breast cancer research : BCR

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent


Tous les auteurs :
Gruel N, Fuhrmann L, Lodillinsky C, Benhamo V, Mariani O, Cédenot A, Arnould L, Macgrogan G, Sastre-Garau X, Chavrier P, Delattre O, Vincent-Salomon A

Résumé

Polarity defects are a hallmark of most carcinomas. Cells from invasive micropapillary carcinomas (IMPCs) of the breast are characterized by a striking cell polarity inversion and represent an interesting model for the analysis of polarity abnormalities.

Mots clés

Breast Neoplasms, genetics, Carcinogenesis, genetics, Cell Line, Tumor, Cell Polarity, genetics, Cell Proliferation, genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Lymphatic Metastasis, Membrane Proteins, biosynthesis, Neoplasm Invasiveness, genetics

Référence

Breast Cancer Res.. 2016 Feb;18(1):23