Prognostic value of transcriptomic determination of tumour-infiltrating lymphocytes in localised breast cancer.
Fiche publication
Date publication
septembre 2019
Journal
European journal of cancer (Oxford, England : 1990)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent, Pr GHIRINGHELLI François, Dr LADOIRE Sylvain, Mme TRUNTZER Caroline
Tous les auteurs :
Truntzer C, Isambert N, Arnould L, Ladoire S, Ghiringhelli F
Lien Pubmed
Résumé
Tumour-infiltrating lymphocyte (TIL) detection by histology is associated with outcomes in breast cancer; nevertheless, analysis standardisation is difficult. We determined whether transcriptomic data could generate a genomic signature that estimated TIL infiltrates and determined patient prognosis in localised breast cancer.
Mots clés
Biostatistics, Breast, Gene expression signatures, Immunology, Tumour-infiltrating lymphocytes
Référence
Eur. J. Cancer. 2019 Sep 6;120:97-106