Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tous les auteurs :
Thuringer D, Garrido C
Brain microvascular endothelial cells (BMECs) interact with astrocytes and pericytes to form the blood-brain barrier (BBB). Their compromised function alters the BBB integrity, which is associated with early events in the pathogenesis of cancer, neurodegenerative diseases, and epilepsy. Interestingly, these conditions also induce the expression of heat shock proteins (HSPs). Here we review the contribution of major HSP families to BMEC and BBB function. Although investigators mainly report protective effects of HSPs in brain, contrasted results were obtained in BMEC, which depend both on the HSP and on its location, intra- or extracellular. The therapeutic potential of HSPs must be scrupulously analyzed before targeting them in patients to reduce the progression of brain lesions and improve neurologic outcomes in the long term.-Thuringer, D., Garrido, C. Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?
brain injury, extracellular vesicles, heat shock protein, microvascular endothelial cells
FASEB J.. 2019 Jul 26;:fj201900895R