Effect of exercise on lung-perfusion scanning in patients with bronchogenic carcinoma.
Fiche publication
Date publication
septembre 2002
Journal
The European respiratory journal
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARIE Pierre-Yves, Pr OLIVIER Pierre, Pr CHENUEL Bruno
Tous les auteurs :
Chenuel B, Haouzi P, Olivier P, Marie PY, Chalon B, Borrelly J
Lien Pubmed
Résumé
The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a ramp-like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean+/-SD: -9+/-6% versus -10+/-4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (-11% and -17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.
Mots clés
Adenocarcinoma, diagnostic imaging, Aged, Carcinoma, Bronchogenic, diagnostic imaging, Carcinoma, Squamous Cell, diagnostic imaging, Exercise Test, Female, Forced Expiratory Volume, Humans, Lung, diagnostic imaging, Lung Neoplasms, diagnostic imaging, Male, Middle Aged, Pulmonary Circulation, Radionuclide Imaging, Radiopharmaceuticals, Technetium Tc 99m Aggregated Albumin, Ventilation-Perfusion Ratio
Référence
Eur. Respir. J.. 2002 Sep;20(3):710-6