Intra-arterial idarubicin_lipiodol without embolisation in hepatocellular carcinoma: The LIDA-B phase I trial.
Fiche publication
Date publication
février 2018
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JOUVE Jean-Louis, Pr LEPAGE Côme, Dr MINELLO Anne, Pr LOFFROY Romaric, Pr SCHMITT Antonin, Dr WENDREMAIRE Maeva
Tous les auteurs :
Guiu B, Jouve JL, Schmitt A, Minello A, Bonnetain F, Cassinotto C, Piron L, Cercueil JP, Loffroy R, Latournerie M, Wendremaire M, Lepage C, Boulin M
Lien Pubmed
Résumé
Idarubicin shows high cytotoxicity against hepatocellular carcinoma (HCC) cells, a high hepatic extraction ratio, and high lipophilicity leading to stable emulsions with lipiodol. A dose-escalation phase I trial of idarubicin_lipiodol (without embolisation) was conducted in patients with cirrhotic HCC to estimate the maximum-tolerated dose (MTD) and to assess the safety, efficacy, and pharmacokinetics of the drug, and the health-related quality of life achieved by patients.
Mots clés
Chemolipiodolisation, Hepatocellular carcinoma, Idarubicin, Phase I
Référence
J. Hepatol.. 2018 Feb 8;: