A high F-FDOPA uptake is associated with a slow growth rate in diffuse Grade II-III gliomas.
Fiche publication
Date publication
avril 2018
Journal
The British journal of radiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles, Pr MARIE Pierre-Yves, Pr TAILLANDIER Luc, Pr GAUCHOTTE Guillaume, Pr VERGER Antoine, Dr RECH Fabien
Tous les auteurs :
Isal S, Gauchotte G, Rech F, Blonski M, Planel S, Chawki MB, Karcher G, Marie PY, Taillandier L, Verger A
Lien Pubmed
Résumé
In diffuse Grade II-III gliomas, a high 3,4-dihydroxy-6-(F)-fluoro-L-phenylalanine (F-FDOPA) positron emission tomography (PET) uptake, with a standardized uptake value (SUV)/contralateral brain tissue ratio greater than 1.8, was previously found to be consistently associated with the presence of an isocitrate dehydrogenase (IDH) mutation, whereas this mutation is typically associated with a better prognosis. This pilot study was aimed to ascertain the prognostic value of this high F-FDOPA uptake in diffuse Grade II-III gliomas with regard to the velocity of diameter expansion (VDE), which represents an established landmark of better prognosis when below 4 mm per year.
Mots clés
Adult, Brain Neoplasms, diagnostic imaging, Dihydroxyphenylalanine, analogs & derivatives, Disease Progression, Female, Glioma, diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Grading, Pilot Projects, Positron-Emission Tomography, methods, Prognosis, Radiopharmaceuticals, pharmacokinetics, Retrospective Studies
Référence
Br J Radiol. 2018 Apr;91(1084):20170803