Induction of pyroptosis in colon cancer cells by LXRβ.
Fiche publication
Journal
Molecular & cellular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François, Dr REBE Cédric, Dr DERANGERE Valentin
Tous les auteurs :
Rébé C, Derangère V, Ghiringhelli F
Lien Pubmed
Résumé
Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in cancer treatment.
Mots clés
Caspase-1, LXR, NLRP3 pannexin 1, colon cancer, pyroptosis
Référence
Mol Cell Oncol. ;2(1):e970094