Influence of fractalkine receptor gene polymorphisms V249I-T280M on cancer occurrence after renal transplantation.
Fiche publication
Date publication
mars 2013
Journal
Transplantation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Pr CHALOPIN Jean-Marc, Pr DUCLOUX Didier, Dr FERRAND Christophe
Tous les auteurs :
Courivaud C, Bamoulid J, Loupy A, Deschamps M, Ferrand C, Simula-Faivre D, Tiberghien P, Chalopin JM, Legendre C, Thervet E, Borg C, Saas P, Ducloux D
Lien Pubmed
Résumé
Fractalkine (CX3CL1) and its receptor (CX3CR1) are involved in antitumor immunity. Two common single nucleotide polymorphisms of the CX3CR1 gene, V249I and T280M, have been associated with reduced fractalkine signaling characterized by decreased adhesive function, signaling, and chemotaxis of leukocytes. We hypothesized that a renal transplant recipient (RTR) carrying the homozygous I249M280 genotype could experience more cancer due to lower CX3CL1-dependent antitumorigenic effects.
Mots clés
Adult, Female, Genetic Predisposition to Disease, Humans, Immunity, Innate, Kidney Transplantation, adverse effects, Male, Middle Aged, Neoplasms, genetics, Polymorphism, Single Nucleotide, Proportional Hazards Models, Receptors, Chemokine, genetics
Référence
Transplantation. 2013 Mar;95(5):728-32