Fungal peptides from pneumonitis hypersensitivity etiologic agents are able to induce specific cellular immune response.
Fiche publication
Date publication
janvier 2017
Journal
Journal of immunological methods
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Dr GODET Yann
Tous les auteurs :
Bellanger AP, Lignon T, Godet Y, Rognon B, Reboux G, Gbaguidi-Haore H, Borg C, Millon L
Lien Pubmed
Résumé
Hypersensitivity pneumonitis (HP) is an immunoallergic disease due to chronic exposure to high quantities of different microorganisms such as Mycobacterium immunogenum (Mi), a mycobacterium, and Lichtheimia corymbifera (Lc), a filamentous fungus. It has recently been demonstrated that the protein DLDH (dihydrolipoyl dehydrogenase), is common to these microorganisms. This study aimed to investigate the immune potential of overlapping peptide pools covering the MiDLDH and LcDLDH.
Mots clés
ELISPOT assay, Epitopes, Hypersensitivity pneumonitis, IFNγ, T cell
Référence
J. Immunol. Methods. 2017 Jan;440:67-73