Tumor destruction using electrochemotherapy followed by CpG oligodeoxynucleotide injection induces distant tumor responses.
Fiche publication
Date publication
septembre 2008
Journal
Cancer immunology, immunotherapy : CII
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
Tous les auteurs :
Roux S, Bernat C, Al-Sakere B, Ghiringhelli F, Opolon P, Carpentier AF, Zitvogel L, Mir LM, Robert C
Lien Pubmed
Résumé
Electrochemotherapy (ECT) is an effective local therapy of human cutaneous cancers but has no effect on distant untreated tumors. We addressed whether tumor-associated antigens released after ECT could induce an efficient systemic immunity when associated with an appropriate immunoadjuvant.
Mots clés
Adjuvants, Immunologic, Animals, Antigens, CD11b, biosynthesis, Antigens, CD11c, biosynthesis, Antineoplastic Agents, pharmacology, CpG Islands, Electrochemotherapy, methods, Female, Immunotherapy, methods, Mice, Mice, Inbred C57BL, Mice, Nude, Neoplasms, genetics, Oligonucleotides, chemistry, Toll-Like Receptor 9, metabolism
Référence
Cancer Immunol. Immunother.. 2008 Sep;57(9):1291-300