Immune classifications with cytotoxic CD8(+) and Th17 infiltrates are predictors of clinical prognosis in glioblastoma.
Fiche publication
Date publication
janvier 2017
Journal
Oncoimmunology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERTAUT Aurélie, Dr BOIDOT Romain, Pr GHIRINGHELLI François, Dr LADOIRE Sylvain, Mme TRUNTZER Caroline, Dr VINCENT Julie, Dr LIMAGNE Emeric, Dr DERANGERE Valentin
Tous les auteurs :
Madkouri R, Kaderbhai CG, Bertaut A, Truntzer C, Vincent J, Aubriot-Lorton MH, Farah W, Limagne E, Ladoire S, Boidot R, Derangère V, Ghiringhelli F
Lien Pubmed
Résumé
Interest is growing on immune cells involvement in central nervous system tumors such as glioblastoma. Even if a few reports highlighted that immune classifications could have a prognostic value, no paradigm has been clearly yet established on large and homogeneous cohorts. The aim of our study was to analyze the prognostic role of the in situ immune response of cytotoxic T cells (i.e., CD8(+)), Foxp3 cells, Th17 and tumor-associated macrophages in glioblastoma on two independent large and homogeneous cohorts.
Mots clés
Angiogenesis, CD8+ T cells, Th17 T cells, glioblastoma, immune infiltrate
Référence
Oncoimmunology. 2017 ;6(6):e1321186