Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer.
Fiche publication
Date publication
septembre 2007
Journal
Annals of oncology : official journal of the European Society for Medical Oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COUTANT Charles
Tous les auteurs :
Coutant C, Barranger E, Cortez A, Dabit D, Uzan S, Bernaudin JF, Darai E
Lien Pubmed
Résumé
It has been suggested that histologically undetectable or 'occult' metastases in the lymphatic system could explain some recurrences. HPV DNA screening by means of the polymerase chain reaction (PCR) has been proposed as a method to detect occult metastases. This study was designed to determine the frequency of HPV DNA detection by PCR in sentinel lymph node (SN), and its relation to the clinical characteristics and outcome of women with cervical cancer.
Mots clés
Adult, Aged, Alphapapillomavirus, isolation & purification, DNA, Viral, isolation & purification, Female, Humans, Lymph Nodes, virology, Lymphatic Metastasis, Middle Aged, Prognosis, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms, virology
Référence
Ann. Oncol.. 2007 Sep;18(9):1513-7