Clues pointing to simple hysterectomy to treat early-stage cervical cancer.

Date publication

octobre 2009

Journal

Oncology reports

Auteurs

Membres identifiés du Cancéropôle Est :
Pr COUTANT Charles

Tous les auteurs :
Coutant C, Cordier AG, Guillo E, Ballester M, Rouzier R, Daraï E

Lien Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19724875

Résumé

Radical hysterectomy and pelvic lymphadenectomy is recommended for stage Ia2-Ib1 cervical cancer while parametrial involvement (PI) is rare. Our aim was to evaluate criteria to select women with low risk of PI that could benefit from simple hysterectomy. Factors associated with low risk of PI were analyzed in a series of 37 patients with stage Ia2-Ib1 cervical cancer undergoing radical hysterectomy and sentinel lymph node procedure from 2003 to 2008. PI was associated with tumor size (p<0.001) and lymphovascular space invasion (LVSI) (p=0.007). PI was found in 4.5% of patients with tumor size 2 cm (p=0.04). The negative predictive value was 100% for absence of LVSI (95% CI: 0.83-1) and for combinations: tumor size

Mots clés

Adult, Aged, Aged, 80 and over, Female, Humans, Hysterectomy, methods, Middle Aged, Neoplasm Staging, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms, pathology

Référence

Oncol. Rep.. 2009 Oct;22(4):927-34