Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.
Fiche publication
Date publication
octobre 2010
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COUTANT Charles
Tous les auteurs :
Bianchini G, Qi Y, Alvarez RH, Iwamoto T, Coutant C, Ibrahim NK, Valero V, Cristofanilli M, Green MC, Radvanyi L, Hatzis C, Hortobagyi GN, Andre F, Gianni L, Symmans WF, Pusztai L
Lien Pubmed
Résumé
The purpose of this study was to identify genes enriched in breast cancer stroma, assess the stromal gene expression differences between estrogen receptor (ER) -positive and -negative cancers, and separately determine their prognostic value in these two subtypes of breast cancers.
Mots clés
Amyloid beta-Protein Precursor, genetics, Antineoplastic Agents, Hormonal, therapeutic use, B-Lymphocytes, pathology, Biopsy, Fine-Needle, Breast Neoplasms, drug therapy, Chi-Square Distribution, Collagen Type IV, genetics, Extracellular Matrix Proteins, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Metagenome, genetics, Neoplasm Recurrence, Local, Phospholipid Transfer Proteins, genetics, Prognosis, Proportional Hazards Models, Prospective Studies, Protease Nexins, Protein-Serine-Threonine Kinases, genetics, Receptors, Cell Surface, genetics, Receptors, Estrogen, genetics, Receptors, Transforming Growth Factor beta, genetics, Survival Analysis, Tamoxifen, therapeutic use
Référence
J. Clin. Oncol.. 2010 Oct;28(28):4316-23