The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.
Fiche publication
Date publication
janvier 2018
Journal
Journal of the National Cancer Institute
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François, Dr GUENOT Dominique, Pr LEPAGE Côme, Dr DERANGERE Valentin
Tous les auteurs :
Marisa L, Svrcek M, Collura A, Becht E, Cervera P, Wanherdrick K, Buhard O, Goloudina A, Jonchère V, Selves J, Milano G, Guenot D, Cohen R, Colas C, Laurent-Puig P, Olschwang S, Lefèvre JH, Parc Y, Boige V, Lepage C, André T, Fléjou JF, Dérangère V, Ghiringhelli F, de Reynies A, Duval A
Lien Pubmed
Résumé
Immune checkpoint (ICK) expression might represent a surrogate measure of tumor-infiltrating T cell (CTL) exhaustion and therefore be a more accurate prognostic biomarker for colorectal cancer (CRC) patients than CTL enumeration as measured by the Immunoscore.
Mots clés
Antigens, CD, genetics, B7-H1 Antigen, analysis, Biomarkers, Tumor, genetics, CD8 Antigens, analysis, CTLA-4 Antigen, genetics, Colon, chemistry, Colorectal Neoplasms, chemistry, Female, Gene Expression, Hepatitis A Virus Cellular Receptor 2, genetics, Humans, Inducible T-Cell Co-Stimulator Protein, genetics, Lymphocytes, Tumor-Infiltrating, Male, Microsatellite Instability, Middle Aged, Neoplasm Staging, Prognosis, Programmed Cell Death 1 Ligand 2 Protein, genetics, Programmed Cell Death 1 Receptor, genetics, Retrospective Studies, Survival Rate, T-Lymphocytes, Cytotoxic, Th1 Cells
Référence
J. Natl. Cancer Inst.. 2018 Jan 1;110(1):