[Case-control study evaluating the incidence of hyperhomocysteinemia in cancer patients in an internal medicine department]
Fiche publication
Date publication
août 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BONNOTTE Bernard, Pr GHIRINGHELLI François
Tous les auteurs :
Falvo N, Ghiringhelli F, Berthier S, Bonnotte B, Lorcerie B
Lien Pubmed
Résumé
PURPOSE: Cancer is a cause of venous thromboembolism. However, the physiopathology remains unknown. Hyperhomocysteinemia could be a promoting factor. METHOD: We built a case-control study of 65 patients followed for 2 years to compare levels of homocysteinemie in cancer bearing patients with that in matched cancer free control patients. RESULTS: Fifty per cent of cancer bearing patients had significantly increased blood serum levels of homocysteine (P=0.006). This increase did not correlate with any deficiency in blood serum levels of folate or vitamin B12. CONCLUSION: High levels of homocysteinemie could be linked to tumor proliferation.
Référence
Rev Med Interne. 2007 Aug;28(8):520-5