Risk assessment of second primary cancer according to histological subtype of non-Hodgkin lymphoma.

Fiche publication

Date publication

février 2015


Membres identifiés du Cancéropôle Est :
Dr CASASNOVAS Olivier, Pr MAYNADIE Marc, Pr VELTEN Michel, Dr WORONOFF Anne-Sophie, Dr ROSSI Cédric

Tous les auteurs :
Rossi C, Jegu J, Mounier M, Dandoit M, Colonna M, Daubisse-Marliac L, Tretarre B, Ganry O, Guizard AV, Bara S, Bouvier V, Woronoff AS, Monnereau A, Casasnovas O, Velten M, Troussard X, Maynadie M


Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of diseases that is known to carry a considerable risk of second primary cancer (SPC). However, little attention has been paid to SPC risk assessment according to NHL subtypes. Data from 10 French population-based cancer registries were used to establish a cohort of 7,546 patients with a first diagnosis of NHL (eight subtypes) between 1989 and 2004. Standardized incidence ratios (SIRs) of metachronous SPC were estimated. Among the 7,546 patients diagnosed with a NHL, the overall SPC risk was 25% higher than that in the reference population (SIR = 1.25 95% CI 1.15-1.36). In univariate analysis, the SPC risk differed by lymphoma subtype. Interestingly, multivariate analysis showed that SPC risk did not differ significantly across NHL subtypes after adjustment for the other covariates (p=0.786). NHL patients have an increased risk of SPC that is not influenced by the histological NHL subtype.


Leuk Lymphoma. 2015 Feb 2:1-23.