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Characterization of cell-fate decision landscapes by estimating transcription factor dynamics.

Jiménez S, Schreiber V, Mercier R, Gradwohl G, Molina N

Cell Rep Methods. 2023 07 24;3(7):100512

Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice.

Blot F, Marchix J, Ejarque M, Jimenez S, Meunier A, Keime C, Trottier C, Croyal M, Lapp C, Mahe MM, De Arcangelis A, Gradwohl G

Cell Mol Gastroenterol Hepatol. 2023 02 27;:

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.

Schreiber V, Mercier R, Jiménez S, Ye T, García-Sánchez E, Klein A, Meunier A, Ghimire S, Birck C, Jost B, Honnens de Lichtenberg K, Honoré C, Serup P, Gradwohl G

Mol Metab. 2021 Aug 2;:101313

Adhesion Receptor Adgrg2/Gpr64 Is In The Gi-Tract Selectively Expressed In Mature Intestinal Tuft Cells.

Grunddal KV, Tonack S, Egerod KL, Thompson JJ, Petersen N, Engelstoft MS, Vagne C, Keime C, Gradwohl G, Offermanns S, Schwartz TW

Mol Metab. 2021 Apr 5;:101231

Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine.

Li HJ, Ray SK, Kucukural A, Gradwohl G, Leiter AB

Cell Mol Gastroenterol Hepatol. 2020 Aug 18;:

is required to specify a subset of ventromedial hypothalamic neurons.

Aslanpour S, Rosin JM, Balakrishnan A, Klenin N, Blot F, Gradwohl G, Schuurmans C, Kurrasch DM

Development. 2020 Apr 6;:

Ascl1 is required to specify a subset of ventromedial hypothalamic neurons.

Aslanpour S, Rosin JM, Balakrishnan A, Klenin N, Blot F, Gradwohl G, Schuurmans C, Kurrasch DM

Development. 2020 Jan 1;:

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.

Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G

Mol Metab. 2019 Nov;29:24-39

A transcriptomic roadmap to alpha- and beta cell differentiation in the embryonic pancreas.

van Gurp L, Muraro MJ, Dielen T, Seneby L, Dharmadhikari G, Gradwohl G, van Oudenaarden A, de Koning EJP

Development. 2019 Jun 3;:

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage.

De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, Gradwohl G, Baeyens L, Heremans Y, Martens GA, De Leu N, Sojoodi M, Van de Casteele M, Heimberg H

Cell Death Dis. 2016 Jun;7(6):e2272

Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas.

Nivlet L, Herrmann J, Martin DE, Meunier A, Orvain C, Gradwohl G

J. Mol. Endocrinol.. 2016 Feb;56(2):77-90

Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic beta- and alpha-Cells.

Mohan R, Mao Y, Zhang S, Zhang YW, Xu CR, Gradwohl G, Tang X

J Biol Chem. 2015 Aug 7;290(32):19955-66

Pairing-up SOX to kick-start beta cell genesis.

Grapin-Botton A, Seymour PA, Gradwohl G

Diabetologia. 2015 Mar 4.

Rfx6 maintains the functional identity of adult pancreatic beta cells.

Piccand J, Strasser P, Hodson DJ, Meunier A, Ye T, Keime C, Birling MC, Rutter GA, Gradwohl G

Cell Rep. 2014 Dec 24;9(6):2219-32

Pak3 promotes cell cycle exit and differentiation of beta-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.

Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G

Diabetes. 2014 Jan;63(1):203-15

Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.

De Leu N, Heremans Y, Coppens V, Van Gassen N, Cai Y, D'Hoker J, Magenheim J, Salpeter S, Swisa A, Khalaileh A, Arnold C, Gradwohl G, Van de Casteele M, Keshet E, Dor Y, Heimberg H

Diabetologia. 2014 Jan;57(1):140-7.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stange G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H

Nat Biotechnol. 2014 Jan;32(1):76-83

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity.

Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL

Dis Model Mech. 2013 Sep;6(5):1133-45

Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes.

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P

Dev Cell. 2013 Jul 15;26(1):86-100

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development.

Beucher A, Martin M, Spenle C, Poulet M, Collin C, Gradwohl G

Dev Biol. 2012 Jan 15;361(2):277-85

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, Gradwohl G

PLoS One. 2012;7(5):e36449

Enteroendocrine cells and lipid absorption.

Mellitzer G, Gradwohl G

Curr Opin Lipidol. 2011 Jun;22(3):171-5.

Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.

Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL

Dev Biol. 2011 Jan 15;349(2):406-16

Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.

Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G

J Clin Invest. 2010 May 3;120(5):1708-21

Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice.

Arai Y, Gradwohl G, Kameda Y

Cell Tissue Res. 2010 Apr;340(1):137-45

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.

Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G

Development. 2010 Jan;137(2):203-12.

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Petrova TV, Nykanen A, Norrmen C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K

Cancer Cell. 2008 May;13(5):407-19.

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Xu X, D'Hoker J, Stange G, Bonne S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H

Cell. 2008 Jan 25;132(2):197-207.