Fiche publication
Date publication
août 2026
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
Guha S, Re J, Grégoire S, Chemarin M, Augereau A, Messaoud-Nacer Y, Le Hars P, Chamma H, Bergas V, McNairy C, Nguyen J, Barrat J, Pais de Barros JP, Woznica A, Acar N, Vila IK, Boudinot P, Laguette N
Lien Pubmed
Résumé
The stimulator of interferon genes (STING) is a pivotal regulator of type I interferon (IFN) responses. Although the IFN system is confined to vertebrates, STING is present across metazoans and in some unicellular eukaryotes, suggesting involvement in distinct functions prior to vertebrate divergence. Here we explore the conservation of STING-mediated regulation of polyunsaturated fatty acid (PUFA) metabolism. We find that STING homologs from vertebrates, invertebrates, and unicellular eukaryotes interact with fatty acid desaturase 2 (FADS2), the rate-limiting enzyme in PUFA metabolism, and influence subsequent functional outputs. Specifically, we show that STING homologs differentially shape cell susceptibility to infection by DNA and RNA viruses independently of the activation of IFN responses, suggesting that STING-mediated metabolic pathway regulation may participate in primitive host defense mechanisms. Thus, we identify STING-mediated metabolic regulation as an evolutionarily conserved feature and a primordial function of STING.
Mots clés
Animals, Membrane Proteins, metabolism, STING Protein, Lipid Metabolism, genetics, Fatty Acid Desaturases, metabolism, Evolution, Molecular, Humans, Fatty Acids, Unsaturated, metabolism, Mice, Phylogeny, Interferon Type I, metabolism, HEK293 Cells
Référence
Nat Commun. 2026 08 14;17(1):
