Fiche publication
Date publication
septembre 2026
Journal
Anticancer research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ROYER Bernard
,
Dr RECH Fabien
Tous les auteurs :
Chauffert B, Galmiche A, Louandre C, Royer B, Simonet M, Guilain N, Rech F, Simonet P, Sibert M, Abdaoui A, Cau A, Boone M, Beaurain J
Lien Pubmed
Résumé
Poor prognosis of brain tumors is partly related to the blood brain barrier (BBB) to hydrophilic anticancer drugs. Early studies demonstrated that intracranial injection of vital dyes bypassed BBB in cats. We investigated if intraventricular infusion of gemcitabine can circumvent the blood-brain barrier and achieve therapeutically relevant drug concentrations within the brain and cerebrospinal fluid.
Mots clés
Gemcitabine, blood-brain barrier, glioblastoma, glymphatic system, intraventricular infusion, meningeal metastasis
Référence
Anticancer Res. 2026 09;46(9):4827-4840
