Fiche publication
Date publication
juillet 2026
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLAYE Pierre-Simon
Tous les auteurs :
Pedron S, Martinez de Lizarrondo S, D'Arco L, Malherbe J, Trébel S, Tashkandi J, Alt K, Galy B, Bellaye PS, Vigne J, Vivien D, Gauberti M, Bonnard T
Lien Pubmed
Résumé
Timely and sensitive detection of inflammatory and infectious lung diseases remains a major clinical challenge. Current diagnostic approaches often identify pathology only at advanced stages, leaving gaps in acute triage, fibrotic activity assessment, transplant rejection monitoring and inflammation follow-up. Magnetic Particle Imaging (MPI) offers a sensitive, background-free, whole-body imaging modality without ionizing radiation. Here, we present immuno-Magnetic Particle Imaging (immuno-MPI) using micron-sized iron oxide particles targeted to VCAM-1, a key marker of endothelial inflammation. In three lung inflammation models in male mice, MPIO@αVCAM-1 generates high-contrast images within 3 minutes following intravenous injection at 1 mg/kg, with rapid accumulation at the inflamed endothelium and fast clearance of unbound particles. Predominantly confined to the vasculature, these particles selectively target VCAM-1 and discriminate inflamed from healthy lungs at doses as low as 0.18 mg/kg (7.5 µg iron). Specificity for VCAM-1 is confirmed by the absence of signal using control antibodies (MPIO@IgG) and competitive blocking with free αVCAM-1 antibodies. Overall, immuno-MPI provides a non-invasive approach that avoids ionizing radiation and supports pulmonary inflammation monitoring.
Mots clés
Animals, Male, Pneumonia, diagnostic imaging, Vascular Cell Adhesion Molecule-1, metabolism, Magnetic Particle Imaging, methods, Mice, Lung, pathology, Ferric Compounds, chemistry, Mice, Inbred C57BL, Disease Models, Animal
Référence
Nat Commun. 2026 07 23;17(1):
