Quality and pratical determinants in [Tc]Tc-tetrofosmin preparation: hygrometry, syringe sorption & maximal activity per kit.

Fiche publication

Date publication

juin 2026

Journal

EJNMMI radiopharmacy and chemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr IMPERIALE Alessio , Dr DORY Anne

Tous les auteurs :
Buon Q, Tep H, Bassi E, Imperiale A, Dory A, Gourieux B, Ressault A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42230469

Résumé

Tetrofosmin, labelled with technetium-99m ([Tc]Tc-tetrofosmin), is a widely used radiopharmaceutical for myocardial perfusion imaging. Despite its routine use, several practical aspects of its preparation remain insufficiently characterized. This study addressed three operational issues: (i) the potential impact of environmental hygrometry on radiochemical purity assessment using ITLC-SA, as current guidelines provide no recommendations for humidity during quality control; (ii) the extent of sorption in medical syringes, comparing two-part and lubricated three-part syringes due to the lipophilic nature of tetrofosmin; and (iii) the radiochemical conformity of preparations performed with activities exceeding the 12-GBq limit stated in the manufacturer's instructions.