Platelet FcγRIIA is dispensable for hemostasis and arterial thrombosis in the absence of FcγRIIA-specific extracellular stimuli.

Fiche publication

Date publication

juillet 2026

Journal

Research and practice in thrombosis and haemostasis

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MANGIN Pierre

Tous les auteurs :
Tupin F, Magnenat S, Mouriaux C, Mangin PH, Hechler B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42592130

Résumé

FcγRIIA, a high-affinity receptor for immunoglobulin G immune complexes with no ortholog in mice, has a prominent role in host defense against pathogens via immune cell activation. A role for platelet FcγRIIA in enhancing thrombosis was suggested, involving interplay between αβ integrin and FcγRIIA, without requiring FcγRIIA-specific extracellular stimuli. Recent data challenged this view, showing that FcγRIIA inhibition neither impaired platelet spreading on fibrinogen nor prevented thrombus growth and stability under flow.