Intra-Arterial thrombolysis after SUCCESSful angiographic recanalization in acute large-vessel occlusion stroke of the anterior circulation (IA-SUCCESS): a multicentre, randomised, clinical trial protocol.

Date publication

juillet 2026

Journal

European stroke journal

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUILLEMIN Francis

Tous les auteurs :
Gory B, Richard S, Pop R, Wolff V, Cherifi A, Bretzner M, Henon H, Marnat G, Sibon I, Gentric JC, Timsit S, Di Caterino F, Charbonnier G, Caroff J, Denier C, Consoli A, Lapergue B, Allard J, Gerschenfeld G, Dumas V, Lamy M, Richter SJ, Castagnet H, Veunac L, Bourgeois-Beauvais Q, Desilles JP, Seners P, Naggara O, Januel AC, Fontaine L, Boulouis G, Pasi M, Dargazanli C, Arquizan C, Heck O, Garambois K, Comby PO, Bejot Y, Zhu F, Liao L, Loukoul WA, Derelle AL, Anxionnat R, Kamga MM, Hachit H, Guillemin F, Turc G, Hossu G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42439416

Résumé

Intra-arterial thrombolysis (IAT) following successful mechanical thrombectomy (MT) in patients with anterior circulation large-vessel occlusion (LVO) improves cerebral tissue reperfusion and consequently clinical outcome, but has to be validated in non-Asian populations. We hypothesised that IAT with alteplase versus no IAT leads to a better clinical outcome in patients with anterior circulation LVO stroke who have successful angiographic recanalisation.

Mots clés

endovascular treatment, intra-arterial thrombolysis, ischemic stroke, mechanical thrombectomy, protocol, randomized controlled trial

Référence

Eur Stroke J. 2026 07 6;11(7):