Fiche publication
Date publication
juillet 2026
Journal
JCI insight
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
Tous les auteurs :
Desert R, Musso O, Baumert TF
Lien Pubmed
Résumé
The ECM is a dynamic component of the tumor microenvironment with a critical role in cancer progression, invasion, metastasis, immune exclusion, and response to therapy. Recent advances in proteomic analyses investigating the insoluble ECM fractions (termed "matrisome analysis"), along with single-cell RNA sequencing and spatial transcriptomics, have revealed cancer-specific patterns of ECM remodeling. These studies have identified a panel of recurrently upregulated ECM proteins, including annexin A1, fibrillin-1, fibronectin, periostin, and tenascin-C, actively contributing to tumor growth, invasion, angiogenesis, and immune exclusion. The expression of the cancer-associated ECM is largely driven by cancer-associated fibroblasts (CAFs), whose molecular diversity has been dissected through single-cell profiling and consolidated in emerging CAF atlases across cancers. By investigating the matrisome composition and CAF heterogeneity, these studies have unraveled the pivotal role of the stroma in shaping tumor biology. Based on these discoveries, ECM proteins and CAFs are now being explored as biomarkers and therapeutic targets. Future integration of multi-omics datasets with clinical outcomes will help to translate these insights into novel biomarkers for patient stratification and stroma-directed therapeutic interventions.
Mots clés
Humans, Extracellular Matrix, metabolism, Tumor Microenvironment, Neoplasms, pathology, Periostin, Cancer-Associated Fibroblasts, metabolism, Extracellular Matrix Proteins, metabolism, Fibrosis, metabolism, Proteomics, Animals, Biomarkers, Tumor, metabolism, Fibrillin-1, metabolism, Tenascin, metabolism, Annexin A1, metabolism, Fibronectins, metabolism, Adipokines
Référence
JCI Insight. 2026 07 8;11(13):
