Fiche publication
Date publication
juillet 2026
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Christophe
Tous les auteurs :
Ezzi O, Renaudin L, Goetz C, Elnar AA, Azzemou A, Blettner N, Llorens M
Lien Pubmed
Résumé
Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) pose a major global public health challenge, as they are associated with frequent empirical antibiotic treatment failure and increased patient morbidity and mortality. In this context, contact precautions (CP) have traditionally been recommended for hospitalized patients colonized or infected with ESBL-E to prevent healthcare-associated transmission. However, growing evidence has questioned the effectiveness of this strategy in certain care settings. The primary objective of this study is to assess the non-inferiority of standard precautions (SP) compared with clinically triggered CP in reducing the incidence density of ESBL-E acquisition in acute-care geriatric wards. By doing so, this study aims to inform the evaluation of pragmatic infection prevention policies implemented at the institutional level in vulnerable hospital populations.
Mots clés
beta-Lactamases, metabolism, Humans, Enterobacteriaceae Infections, prevention & control, Enterobacteriaceae, enzymology, Prospective Studies, Cross Infection, prevention & control, France, Infection Control, methods
Référence
PLoS One. 2026 07 21;21(7):e0353783
