Knockout of PARP2 in T cells leads to spontaneous colitis with distinct segmental characteristics in PARP1-deficient mice.

Fiche publication

Date publication

mai 2026

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DANTZER Françoise

Tous les auteurs :
Ke H, Kim D, Bencsics M, Bányai B, Csépányi-Kömi R, Sasvári P, Dantzer F, Hanini N, Yélamos J, Tőkés AM, Korsós-Novák Á, Benkő R, Horváth EM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42238594

Résumé

Suppression of poly(ADP-ribose) polymerase (PARP) activity, either PARP1 or PARP2, was proven to be beneficial in experimental colitis. The absence of PARP2 exclusively in T cells (T-PARP2-KO) was also shown recently to exert similar protection. Nevertheless, lower PARP1 expression in the intestines and reduced PARP activity in mononuclear cells from IBD patients were reported. Thus, we would like to investigate the effect of PARP2 deficiency in T cells superimposed on a PARP1 deletion background in the large intestines.