Preclinical feasibility and validation of MRI thermometry dedicated to interstitial photodynamic therapy of glioblastoma.

Fiche publication

Date publication

juin 2026

Journal

Photodiagnosis and photodynamic therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PROUST François

Tous les auteurs :
Gouges B, Dewalle AS, Ozenne V, Desclides M, Baert G, Deleporte P, Derre B, Michel QV, Kuchcinski G, Proust F, Delhem N, Reyns N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42276218

Résumé

Interstitial photodynamic therapy (iPDT) is an emerging loco-regional treatment for glioblastoma based on intracerebral illumination delivered through stereotactically implanted optical fibers. Despite encouraging oncological results, treatment-related morbidity remains significant, and the contribution of unintended light-induced thermal effects has never been experimentally investigated. This study aimed to preclinically characterize temperature changes during illumination using MRI-based thermometry.