Small extracellular vesicle-mediated transfer of HPV16 transcripts from Ca Ski cells increases proliferation of HPV-negative recipient cancer cells.

Fiche publication

Date publication

juin 2026

Journal

Cell communication and signaling : CCS

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen , Dr GOBBO Jessica , Dr LASCOMBE Isabelle , Pr PRETET Jean-Luc , Dr FAUCONNET Sylvie

Tous les auteurs :
Arslan S, Barbaud A, Bernauer J, Avoscan L, Tissot M, Prétet JL, Gobbo J, Garrido C, Lascombe I, Fauconnet S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42298561

Résumé

Tumor-produced extracellular vesicles (EVs) are key players in cancer progression by transferring their bioactive cargo (nucleic acids, lipids, proteins) to target cells leading to increase their proliferation, migration and invasive properties. EVs are involved in virus-associated carcinogenesis. Cervical cancer is due to a persistent infection with a high-risk human papillomavirus (HPV) whose integration into the cellular genome causes the continuous and deregulated expression of viral oncoproteins E6/E7, responsible for the carcinogenesis process. This study aimed to isolate EVs of HPV-infected cells, to explore their viral material content, to determine whether viral cargo can impact the proliferative status of HPV-lacking recipient cells.