Fiche publication
Date publication
juin 2026
Journal
Neurotoxicology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SOULIMANI Rachid
Tous les auteurs :
Kebieche N, Lambert C, Yim S, Soulimani R
Lien Pubmed
Résumé
Developmental neurotoxicity (DNT) arises from disruption of key neurodevelopmental processes-including neural stem cell proliferation, neuronal and glial differentiation, radial migration, and synaptogenesis-that collectively shape corticogenesis. Traditional in vivo guideline studies are costly, low-throughput, and provide limited mechanistic insight, prompting OECD and EFSA to promote new approach methodologies (NAMs) such as the neurosphere assay (NSA).
Mots clés
Chlorpyrifos (CPF), Developmental neurotoxicity (DNT), Neurosphere assay (NSA), New Approach Methodologies (NAMs), Per- and polyfluoroalkyl substances (PFAS), Radial migration, Synaptogenesis
Référence
Neurotoxicology. 2026 06 27;:103501
