High-Resolution Magic Angle Spinning Metabolomic Profiling of IDH-Wild-Type Glioblastoma Reveals a Composite Surgical Sampling Signature Shaped by Clinical and Anatomical Tumor Features.

Date publication

avril 2026

Journal

Metabolites

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques , Dr CEBULA Hélène , Dr BUND Caroline

Tous les auteurs :
Todeschi J, Bund C, Outilaft H, Cebula H, Namer IJ

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42188004

Résumé

Tissue-based metabolomic readouts in IDH-wild-type glioblastoma may be strongly shaped by how tumor tissue is surgically accessed and sampled. We aimed to determine whether, and to what extent, surgical sampling context structures the HRMAS metabolic landscape, and to disentangle sampling-related contributions from clinico-anatomical confounders.

Mots clés

HRMAS NMR, IDH-wild-type, biopsy, glioblastoma, intratumoral heterogeneity, metabolomics, resection, surgical sampling

Référence

Metabolites. 2026 04 27;16(5):