ITPP in early pancreatic zebrafish xenografts mildly impacts tumor cell death without interfering with vascular normalization.

Date publication

mai 2026

Journal

BMC cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie

Tous les auteurs :
Abou Khouzam R, Amorim F, Rifath A, Thaliffdeen L, Ragupathi P, Nawafleh H, Povoa V, Cruz-Ribeiro M, Lehn JM, Fior R, Limani P, Chouaib S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42098650

Résumé

Myo-inositol trispyrophosphate (ITPP) is an anti-hypoxic small molecule that acts as an allosteric effector of hemoglobin in erythrocytes. To capture the early and dynamic effects of ITPP on tumor vasculature and cell viability, we employed a rapid zebrafish xenograft model of pancreatic ductal adenocarcinoma (PDAC) that enables real-time, single-cell-resolution imaging.

Mots clés

Angiogenesis, Combination therapy, Myo-inositol trispyrophosphate (ITPP), Pancreatic cancer, Vascular normalization, Zebrafish xenograft

Référence

BMC Cancer. 2026 05 7;: