Fiche publication
Date publication
mai 2026
Journal
Science (New York, N.Y.)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ERHARDT Mathieu
Tous les auteurs :
Clavel M, Bianchi A, Kobylinska R, Groh R, Zhang X, Ma J, Papareddy RK, Grujic N, Picchianti L, Stewart E, Schutzbier M, Stejskal K, de la Concepcion JC, Sanchez de Medina Hernandez V, Voichek Y, Clauw P, Gunis J, Durnberger G, Muelders JC, Grimm A, Sedivy A, Erhardt M, Vyboishchikov V, Gao P, Lechner E, Vantard E, Potuschak T, Jez J, Roitinger E, Genschik P, Kang BH, Dagdas Y
Lien Pubmed
Résumé
RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that activates selective autophagy to respond to viruses targeting mitochondria, chloroplasts, and the endoplasmic reticulum. Rather than degrading viral components, autophagy selectively removes the immune regulator Enhanced Disease Susceptibility 1 (EDS1) to prevent cell death. This targeted mechanism is mediated by oligomeric metabolic enzymes that moonlight as selective autophagy receptors, linking organelle stress to immune homeostasis. Our findings establish selective autophagy as an essential immune rheostat that fine-tunes defense responses and safeguards cellular integrity to promote host survival during viral infections.
Mots clés
Autophagy, immunology, Arabidopsis, immunology, Arabidopsis Proteins, genetics, Plant Immunity, Plant Diseases, virology, Endoplasmic Reticulum, virology, Cell Survival, Mitochondria, virology, Chloroplasts, virology
Référence
Science. 2026 05 28;392(6801):eadu9554
