Fiche publication
Date publication
mai 2026
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVERNY Gilles
,
Dr DARCQ Emmanuel
Tous les auteurs :
Ozdemir D, Ebner C, Meyer J, Pons F, Champagnol-Di Liberti C, Guimaraes-Olmo I, Rahman MT, Decker AM, Wendling O, Schwartz E, Dumas S, Ehrlich AT, Laverny G, Diana MA, Jin C, Kieffer BL, Darcq E
Lien Pubmed
Résumé
Opioid use disorder is a chronic, relapsing condition that continues to rise worldwide. Naloxone (Narcan®), an opioid antagonist, reverses overdose but triggers strong negative affect. The neuronal circuits underlying these aversive effects remain unclear. We previously identified mu opioid receptor-expressing habenular neurons (Hb-MOR) as key encoders of negative emotional states and hypothesized that they also mediate naloxone aversion.
Référence
Biol Psychiatry. 2026 05 29;:
