Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study.

Fiche publication

Date publication

mai 2026

Journal

Alzheimer's research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BIRCK Catherine

Tous les auteurs :
Allouche A, Colin J, Birck C, Schroeder H, Tallandier V, Baldoni M, Muller C, Afrassi M, Violle N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42067950

Résumé

Aging is the primary risk factor for sporadic Alzheimer's disease (AD). While amyloid-beta oligomers (AβOs) accumulation is a key neuropathological process in AD, their specific effects in aged brains and how aging modulates brain response to AβOs remains poorly understood. We investigated how aging contributes to AβO-induced neurotoxicity and cognitive deficits in mice.