Biological maturation drives the hepatic-to-renal switch in erythropoietin production at birth.

Fiche publication

Date publication

mai 2026

Journal

EBioMedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTIN Laurent , Pr GIRODON François

Tous les auteurs :
Idriss S, Martin L, Maaziz N, Juguet E, Semama D, Merle L, Winter SS, Caillaud A, Marchand A, Girodon F, Gardie B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42090932

Résumé

Erythropoietin (EPO) is essential for erythropoiesis, with production shifting from the foetal liver to the kidney after birth. This hepatic-to-renal transition is a hallmark of neonatal adaptation, but the relative contribution of oxygen exposure versus intrinsic developmental processes remains unclear.