Diagnostic and Prognostic Values of Bile Biomarkers for Malignant Biliary Stenosis.

Fiche publication

Date publication

mai 2026

Journal

Liver international : official journal of the International Association for the Study of the Liver

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SOCKALINGUM Ganesh , Pr THIEFIN Gérard , Dr BOULAGNON-ROMBI Camille

Tous les auteurs :
Gigante E, Untereiner V, Caruso S, Rhaiem R, Grados L, Boulagnon-Rombi C, Adam S, Sockalingum GD, Garnotel R, Thiefin G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/42015571

Résumé

Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour-related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy. This study aimed at evaluating the diagnostic and prognostic values of biliary concentrations of VEGF, PDGF-AA, IGF and MMPs in patients with extrahepatic cholangiocarcinoma (CCA), pancreatic ductal adenocarcinoma (PDAC), or benign obstruction.