High-Relaxivity Gd(III)-Hemicryptophane Complex.

Date publication

avril 2019

Journal

Organic letters

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BOUGUET-BONNET Sabine , Mr LECLERC Sébastien

Tous les auteurs :
Godart E, Long A, Rosas R, Lemercier G, Jean M, Leclerc S, Bouguet-Bonnet S, Godfrin C, Chapellet LL, Dutasta JP, Martinez A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30855968

Résumé

The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.

Référence

Org Lett. 2019 04 5;21(7):1999-2003